张璞（博士，教授）

自2013年9月至2018年6月就读于太阳成集团tyc122cc，分析化学，硕博连读。自2018年7月至2021年11月，在以色列耶路撒冷希伯来大学化学系从事博士后研究，合作导师为中国科学院外籍院士ItamarWillner教授。主要研究领域为DNA纳米技术和新型核酸功能纳米材料，利用发光分析平台，实现了针对miRNA的发光分析传感、细胞成像及药物释放的诊疗一体化研究。迄今为止，共发表文章30余篇，以第一/通讯作者发表SCI文章17篇，其中影响因子大于15的文章5篇，包括Chem. Soc. Rev. 1篇、J. Am. Chem. Soc. 1篇（高被引论文）、ACS Nano3篇、Chem. Sci.4篇、Anal. Chem. 4篇、TrAC 1篇，他引次数1000余次，个人H因子16（基于谷歌学术）。于2021年荣获重庆市科学技术奖一等奖（参与人排名第4），荣获2019年重庆市优秀博士学位论文。主持国家自然科学基金、省部级自然科学基金共4项，省部级教改项目1项。多次指导学生参加“互联网+”项目，分别荣获全国铜奖、市级银奖和校级金奖，“挑战杯”重庆市特等奖。

联系方式 puzhang@swu.edu.cn

学科：分析化学。

研究方向：纳米材料，核酸纳米结构，纳米酶催化，人工细胞合成与应用；

电化学/发光分析，生物传感，荧光成像。

代表性论文

[1] P. Zhang, J. Jiang, R. Yuan, Y. Zhuo, Y. Chai. Highly Ordered And Field-Free 3D DNA Nanostructure: The Next Generation of DNA Nanomachine for Rapid Single-Step Sensing.J. Am. Chem. Soc.,2018,140, 9361-9364.

[2] P. Zhang, Y. Ouyang, Y. S. Sohn, M. Fadeev, O. Karmi, R. Nechushtai, I. Stein, E. Pikarsky, I. Willner. miRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn (II)-Protoporphyrin IX-Loaded Metal-Organic Framework Nanoparticles.ACS nano,2022, 16, 1791-1801.

[3] P. Zhang, Y. Ouyang, Y. S. Sohn, R. Nechushtai, E. Pikarsky, C. Fan, I. Willner. pH-And miRNA-Responsive DNA-Tetrahedra/Metal-Organic Framework Conjugates: Functional Sense-And-Treat Carriers.ACS nano,2021,15, 6645-6657.

[4] P. Zhang, L. Yue, M. Vazquez-Gonzalez, Z. Zhou, W.-H. Chen, Y. S. Sohn, R. Nechushtai, I. Willner. MicroRNA-Guided Selective Release of Loads from Micro-/Nanocarriers Using Auxiliary Constitutional Dynamic Networks.ACS Nano, 2020,14, 1482-1491.

[5] P. Zhang, A. Fischer, Y. Ouyang, Y. S. Sohn, R. Nechushtai, J. J. Zhang, H. Tian, C. H. Fan, I. Willner. Biocatalytic Cascades and Intercommunicated Biocatalytic Cascades in Microcapsule Systems,Chem. Sci.,2022,13,7437-7448.

[6] P. Zhang, A. Fischer, Y. Ouyang, J. Wang, Y. S. Sohn, O. Karmi, R. Nechushtai, I. Willner. Topologically switchable and gated transcription machinery,Chem. Sci.,2022,13,10555-10565.

[7] P. Zhang, A. Fischer, Y. Ouyang, J. Wang, Y. S. Sohn, R. Nechushtai, E. Pikarsky, C. Fan, I. Willner. Aptamer-Modified DNA Tetrahedra-Gated Metal-Organic Framework Nanoparticle Carriers for Enhanced Chemotherapy or Photodynamic Therapy.Chem. Sci.,2021,12, 14473-14483.

[8] P. Zhang, Y. Ouyang, I. Willner. Multiplexed And Amplified Chemiluminescence Resonance Energy Transfer (CRET) Detection of Genes And microRNAs Using Dye-Loaded Hemin/G-quadruplex-Modified UiO-66 Metal-Organic Framework Nanoparticles.Chem. Sci.,2021,12, 4810-4818.

[9] R. Meng , X. Zhang , J. Liu, Y. Zhou, P. Zhang *, Yaqin Chai *, Ruo Yuan *. Dual-layer 3D DNA nanostructure: The next generation of ultrafast DNA nanomachine for microRNA sensing and intracellular imaging.Biosensors and Bioelectronics, 2023,237, 115517.

[10] Pu Zhang,‡ Yu Ouyang,‡ Ying Zhuo, Yaqin Chai, and Ruo Yuan*, Recent Advances in DNA Nanostructures Applied in Sensing Interfaces and Cellular Imaging.Anal. Chem. 2023,95, 407-419.

[11] Pu Zhang, Ying Zhuo, Ya-Qin Chai, Ruo Yuan*, Structural DNA tetrahedra and its electrochemical-related surface sensing. Trends in Analytical Chemistry,2023,160, 116979.